| Early Career | - Portrayed Stephen Hawking in Hawking (2004), BAFTA TV Award nominee
- Amazing Grace (2006) as William Pitt the Younger
- Starter for 10 (2006)
- Atonement (2007)
- The Other Boleyn Girl (2008)
- Creation (2009) as Joseph Hooker
- The Last Enemy (2008)
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| Breakthrough | Sherlock Holmes in Sherlock (2010–2017) |
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| Major Films | - Tinker Tailor Soldier Spy (2011)
- War Horse (2011)
- Star Trek Into Darkness (2013) as Khan
- The Fifth Estate (2013) as Julian Assange
- 12 Years a Slave (2013)
- The Hobbit trilogy (2012–2014) as Smaug/Necromancer (voice/motion capture)
- The Imitation Game (2014) as Alan Turing, Oscar nominee
- The Power of the Dog (2021), Oscar nominee
- Doctor Strange (2016) and subsequent Marvel Cinematic Universe films as Stephen Strange
- The Wonderful Story of Henry Sugar and Three More (2024)
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| Awards | - British Academy Television Award
- Primetime Emmy Award
- Laurence Olivier Award
- CBE (2015) for services to performing arts and charity
- BAFTA Award for best leading actor
- Satellite Award for best leading actor
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| Production | Co-founded SunnyMarch production company (2013) |
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