| At 25, Jorge started working as an editor for the teen magazine Super Pop and went on to work with Pronto. |
| Jorge's first television appearance was in 1997 on Extra Rosa. |
| He transitioned to hosting in 2001 with Rumore, rumore. |
| Jorge became a household name on the TV show Aquí hay tomate in 2003. |
| In May 2011, he became the main host of Supervivientes, which turned out to be the most-watched season. |
| He published his first autobiographical novel in November 2012, titled La vida iba en serio. |
| He hosted Hay una cosa que te quiero decir from 2012 to 2015. |
| His second autobiographical novel, Último verano de juventud, was released in September 2015. |
| An animal lover, Jorge shares his home with several greyhounds and a donkey. |
| Vázquez debuted in theatre production with Miguel de Molina al desnudo in 2014. |
| He acted in Iba en serio, a musical adaptation of his novel in 2015. |
| In 2017, he was a producer for the musical comedy film Holy Camp!. |
| Jorge made a cameo in Shakira's musical album Grandes Éxitos in 2018. |
| In 2023, he was set to host Cuentos Chinos, a new weeknight chat show. |
| He recently appeared on Gran Hermano Season 19 in September 2024. |