| Career Start | 1978 at Oregon Shakespeare Festival |
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| Broadway | Appeared as Marlene Dietrich in biographical play Piaf; Tony Award nomination for Best Actress in a Play for 2000 revival of The Man Who Came to Dinner |
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| Television Breakthrough | Charlene Frazier Stillfield on CBS sitcom Designing Women |
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| Notable TV Roles | - Lana Gardner on NBC's Frasier (2000-2001)
- Regina Newley on ABC's Samantha Who?
- Deborah Vance on HBO's Hacks
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| Film Credits | - The Brady Bunch Movie (1995)
- Guinevere (1999)
- Sweet Home Alabama (2002)
- Garden State (2004)
- I Heart Huckabees (2004)
- Youth in Revolt (2009)
- The Accountant (2016)
- A Simple Favor (2018)
- Babylon
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| Awards | | Primetime Emmy Awards | Seven wins |
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| Golden Globe Awards | Three wins |
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| Screen Actors Guild Awards | Three wins |
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| Grammy Award | Nomination |
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| Tony Award | Nomination |
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| Independent Spirit Award | Nomination for Guinevere (1999) |
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| Critics Choice Awards | Five wins |
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| Historic Achievement | 2021 Emmy win for Outstanding Lead Actress in a Comedy Series for Hacks; joined Betty White as only actors to complete comedy trifecta with Emmy wins in lead, supporting, and guest categories |
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