| Debut | Stage with Colorado Shakespeare Festival (1980); Broadway in Coastal Disturbances (1987); Film in The Great Outdoors (1988) |
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| Breakthrough | The Grifters (1990) |
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| Notable Films | - The Grifters (1990)
- Postcards from the Edge (1990)
- The American President (1995)
- Mars Attacks! (1996)
- American Beauty (1999)
- What Planet Are You From? (2000)
- Being Julia (2004)
- The Kids Are All Right (2010)
- Film Stars Don't Die in Liverpool (2017)
- Death on the Nile (2022)
- Nyad (2023)
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| Recent Works | Apples Never Fall (Peacock miniseries, 2024) |
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| Awards and Nominations | - 5 Academy Award nominations (Best Supporting Actress for The Grifters 1990, Best Actress for American Beauty 1999, Being Julia 2004, The Kids Are All Right 2010, Nyad 2023)
- 2 Golden Globe Awards
- BAFTA Award
- Tony Award nomination for Best Featured Actress in Coastal Disturbances (1987)
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