| Debut | | Film | 'Coming Soon' (1999) |
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| TV | 'Law & Order' (1990) |
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| Awards, Honours, Achievements | - 2006 - Best Ensemble in Television Awards at the Satellite Awards for 'Grey's Anatomy'
- 2007 - Outstanding Performance by an Ensemble in a Drama Series at the Screen Actors Guild Awards
- 2007 - Best Actress – Drama Series at the Satellite Awards for 'Grey's Anatomy'
- 2007 - Special Achievement in Entertaining at the National Italian American Foundation
- 2013 - Favorite TV Drama Actress Award at the People's Choice Awards for 'Grey's Anatomy'
- 2015 - Favorite Dramatic TV Actress Award at the People's Choice Awards for 'Grey's Anatomy'
- 2018 - LGBTQ Community's Supporter Award at the GLSEN Respect Awards
- 2020 - The Female TV Star of 2020 Award at the People's Choice Awards for 'Grey's Anatomy'
- 2021 - The Female TV Star of 2021 Award at the People's Choice Awards for 'Grey's Anatomy'
- 2022 - Honored as a Disney Legend at the Disney Legends Awards
- 2022 - The Female TV Star of 2022 Award at the People's Choice Awards for 'Grey's Anatomy'
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| Notable Productions | - Starred in 'Grey's Anatomy' as Dr. Meredith Grey.
- Founded her own production company 'Calamity Jane'.
- Voiced a character in 'Doc McStuffins'.
- Participated in various films and TV series.
- Executive Producer on 'Grey's Anatomy' (2017–present).
- Co-executive Producer on 'Station 19' (2018–2024).
- Executive Producer on 'Good American Family' miniseries (2025).
- Directed two episodes of 'Grey's Anatomy'.
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| Notable Films | - 'Catch Me If You Can' (2002) - alongside Leonardo DiCaprio
- 'Old School' (2003) - alongside Luke Wilson, Vince Vaughn, and Will Ferrell
- 'The Sisterhood of the Traveling Pants 2' (2008)
- 'Moonlight Mile' (2002) - alongside Jake Gyllenhaal and Dustin Hoffman
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| Salary & Compensation | - 2011 - Signed contract earning $200,000 per episode; named eighth highest-paid TV actress in 2012 with $9 million annual earnings.
- 2018 - Renewed contract for two more seasons; became highest-paid actress in a television drama series earning $575,000 per episode plus $6-7 million annually as producer, totaling over $20 million per year.
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